Although STT3A is critical for EMT-mediated PD-L1 protein induction and tumor immune evasion, the molecular mechanism through which STT3A is transcriptionally regulated in HCC cells remains unknown, we here disclosed that spermine could promote STT3A expression at transcriptional level through activation of Akt/β-catenin pathways. Here, AKT1 is linked to hepatocellular carcinoma.