SLC5A2 and hydrops fetalis: The primary findings of this network meta-analysis are as follows: (i) There were no differences in all-cause and cardiac death between the drug treatments in patients with HFpEF; (ii) ARNIs, ACEIs, and SGLT2 inhibitors significantly reduced HF hospitalization, and only SGLT2 inhibitors reduced the risk of WHF events; and (iii) Angiotensin receptor blockers (ARBs) failed to reduce HF hospitalization.