In T2D model HF/Hfr diet with a single dose of STZlead to cognitive dysfunction, peripheral hyperglycemia, hypercholesterolemia, and insulin resistance (increased HOMA –IR index) together with increased hippocampal GSK-3β and the increase of the deposition of the Aβ1-42 and p-Tau. The gene discussed is GSK3B; the disease is Insulin resistance.