Similarly, IL-1β levels were significantly decreased in the hippocampus of rats received the same dose of PCDE (2.04 ± 0.135 pg/mg protein for T2D + CD150; p < 0.05) (Fig. 4B) and only a significant reduction was observed in the hippocampus of rats treated with 150 mg/kg of PCDE (2.72 ± 0.034 pg/mg protein; p < 0.05). The gene discussed is IL1B; the disease is type 2 diabetes mellitus.