MAPT and Alzheimer disease: In the present work, we aimed to determine the efficacy of PCDE on AD-like alterations, particularly amyloid-beta (Aβ) and P-tau accumulation, induced in T2D rats by a high-fat, high-fructose diet combined with a single small dose of STZ (25 mg/kg i.p.), as well as estimation of its effect on cognitive impairment caused by a single injection of scopolamine.