Also, PCDE induced a significant decline in the hippocampal oxidative damage marker MDA of T2D rats (0.0329 ± 0.00139, 0.0296 ± 0.00195 and 0.0236 ± 0.00199 nmol/mg protein for T2D + CD50, T2D + CD100 and T2D + CD150, respectively; p < 0.01).Donepezil did not produce any significant change in the impaired oxidant/antioxidant balance observed in the brain of diabetic rats. The gene discussed is SEMA4D; the disease is type 2 diabetes mellitus.