Groups IV, V and VI were fed with HF/HFr diet for 8 weeks, injected once with STZ (25 mg/kg; i.p.)and received daily PCDE orally by gavage, emulsified in Tween 80 (1% v/v) at doses of 50 mg/kg (T2D + CD50), 100 mg/kg (T2D + CD100) and 150 mg/kg (T2D + CD150); respectively. This evidence concerns the gene SEMA4D and type 2 diabetes mellitus.