Singh, T. D. et al. studied the promoter methylation of certain tumor associated genes in the molecular pathogenesis of GBC and GSD and revealed that downregulation of SOCS1 only occurred in GBC and methylation frequency increase of 14–3-3 sigma, MASPIN and THBS1 genes from early to advanced GBC grades; with the latter several genes showed in GSD significantly as well [5]. The gene discussed is THBS1; the disease is disorder of glycogen metabolism.