It might be because: there are little data on the role of elevated TG-related biomarkers on gallbladder cancer risk, but HTG, relating to GSD, might decrease sensitivity to cholecystokinin, and increase both biliary cholesterol saturation and bile viscosity enhancing mucin production [25, 26], and cholesterol stones and gallbladder infections were associated with increased MUC3 and MUC5B expression [27]. This evidence concerns the gene CCK and gallbladder cancer.