YTHDF1 activated RhoA signaling by binding to the m6A site of ARHGEF2 messenger RNA, leading to enhanced translation of ARHGEF2, and the YTHDF1-m6A-ARHGEF2 axis promoted the growth of CRC cell lines in primary organs as well as in lung and liver metastases [59]. Here, ARHGEF2 is linked to colorectal carcinoma.