On the other hand, BPCs are one of the most common causes of the ectopic ACTH syndrome (EAS), a syndrome which means the adrenocorticotropic hormone (ACTH) is over produced by nonpituitary tumors, inducing hypertension, central obesity, hypokalemia, visceral fat accumulation and which could increase the possibility of surgical difficulties and postoperative implications [7]. This evidence concerns the gene POMC and Hypokalemia.