In our subgroup analyse, the age, tumor size and Ki-67 index in patients with EAS were significantly less, one reason might be these patients could have more obvious clinical manifestations of hypercortisolism, such as hypertension, diabetes mellitus, hypokalemia, central obesity, a buffalo hump, a moon face, acne, and muscle weakness, which could be detected earlier before further progression. This evidence concerns the gene MKI67 and diabetes mellitus.