AKT1 and colorectal carcinoma: Interference of miR-145-5p in SW480 and SW620 cells demonstrated that miR-145-5p played a paradoxical role in the development of CRC, and AKT signaling evoked EMT-mediated anoikis might be the pathway by which miR-145-5p regulates CRC cell invasion and metastasis (Fig. 7).