The most common AEs were fatigue (11.5%), rash (8.9%), pruritus (6.4%), diarrhea (5.1%), increased aspartate/alanine aminotransferase levels (5.1%), decreased appetite (3.8%), decreased body weight (2.6%), nausea (2.6%), hypothyroidism (2.6%), hypersensitivity/infusion-related reaction (2.6%), and hyperthyroidism (1.3%). The gene discussed is GPT; the disease is hypothyroidism.