XBP1 and retinal ischemia: Previous studies also confirmed the roles of Xbp1 in modulating angiogenesis in the conditions of tumor [47], retinal ischemia [48], cardiac ischemia [49], etc. Combing the above evidence, we therefore supposed that Xbp1 also played an essential role in modulating angiogenesis under MCAO condition, possibly via enhancing the healing EC phenotype and stemness.