Previous studies also confirmed the roles of Xbp1 in modulating angiogenesis in the conditions of tumor [47], retinal ischemia [48], cardiac ischemia [49], etc. Combing the above evidence, we therefore supposed that Xbp1 also played an essential role in modulating angiogenesis under MCAO condition, possibly via enhancing the healing EC phenotype and stemness. Here, XBP1 is linked to neoplasm.