In murine models of endotoxin-induced ARDS, an intact inflammatory reflex, and its induction through administration of α7-nACh-R agonists and pyridostigmine are crucial to reducing lung and systemic inflammation and decreasing mortality (Su et al. 2010; Pinheiro et al. 2021; Bricher Choque et al. 2021). Here, CHRNA7 is linked to acute respiratory distress syndrome.