Moreover, the data from fluorescence resonance energy transfer, MTT, Ki67 immunostaining, immunohistochemistry (IHC) assays demonstrated that Ser194-phosphorylated FADD was localized in the nucleus of tumor cells and induced proliferation in multiple types of cancer, including T-cell lymphoblastic lymphoma, CRC, and lung cancer (Bhojani et al. 2005; Marikar et al. 2016; Marin-Rubio et al. 2019a). Here, FADD is linked to colorectal carcinoma.