FADD and cancer: Ranjan et al. performed luciferase reporter and p65 translocation assays and discovered that FADD overexpression blocked NF-κB activation induced by TNFα and translocation of p65 from the cytoplasm to the nucleus in MCF-7 cells and colorectal cancer (CRC) cell line HCT 116 (Ranjan and Pathak 2016b).The same team chemically conjugated purified FADD protein with cell permeable TAT (transactivator of transcription) peptide in another study, to deliver in cancer cells.