In particularwe observed a decrease in the HDL components APOA4 and APOC1 in both COVID-19 non-ICU and ICU/F patients (cluster 3, Fig. 5A) while APOA2, APOD, APOH, APOM and the HDL-associated PON1 protein appear to be decreased mainly in COVID-19 non-ICU patients (cluster 7, Fig. 5B). The gene discussed is APOA4; the disease is COVID-19.