Concerning platelet functionboth COVID-19 ICU and non-ICU patients show a reduction in structural proteinssuch as VCL, SPARC, PLEK, TLN1, TAGLN2, FLNA (all present in cluster 4Figure 5A) and TMSB4X (cluster 3, Fig. 5A), a possible indication of thrombocytopeniaas already reported in COVID-19 patients [49], while a reduction of secreted platelet factorssuch as PF4 and PPBPwas observed only in COVID-19 non-ICU patients. This evidence concerns the gene PLEK and COVID-19.