Cluster 12 and 13 report proteins that are increased in all COVID-19 patients but at higher levels in ICU/F patients (Fig. 4B) which are mainly constituted by proteins playing a role in acute inflammatory response (CRP, ORM1, ORM2, SAA1, SAA2, S100A8, S100A9, Serpin A3). Here, S100A8 is linked to COVID-19.