Interestinglywe also detected a small set of proteins whose levels are decreased in COVID-19 non-ICU patients and increased in COVID-19 ICU/Fwhich play a role in the complement (C8G, C8B, CFB, C1QB and C1QC, cluster 12 Fig. 5C) and platelet/coagulation (SERPIN A6, SERPIN D1, F2 in cluster 12 and KNG1, PLG in cluster 6 Fig. 5C) cascadesconfirming that these processes may be differently modulated depending on disease severity. This evidence concerns the gene C8B and COVID-19.