BMP10 and anemia (phenotype): To exclude the possibility that the anemia phenotype is caused by the hematological defects seen in R26CreER mice [36], adult R26CreER/+ and R26+/+ (Bmp10+/+ or Bmp102f/+) mice were treated with the same tamoxifen regimen (3 days injections; 100 μg/g bw).