It also found that melatonin can regulate AMPK/mTOR signaling pathway and play a protective role in myocardial ischemia reperfusion [14], reduce the neuron apoptosis induced by focal cerebral ischemia in mice via activating the PI3K/Akt signaling pathway [39], and alleviate nerve defects caused by middle cerebral artery occlusion in adult male rats through activating Akt/mTOR signaling pathway [40]. Here, AKT1 is linked to myocardial ischemia.