CASP8 and neoplasm: In addition, the hexane fraction of the methanol extract (50 mg/kg) of S. lyratum showed similar inhibitory activity on tumor growth in mice with Lewis lung carcinoma tumor, potentially acting through up-regulating Fas, caspase-8, caspase-3, and p53, and down-regulating FasL and B-cell lymphoma-2 (Bcl-2) in the mitochondrial pathway [27, 79].