The qRT-PCR results showed that METTL3 knockdown significantly decreased the expression of miR-196b but increased the expression of pri-miR-196b in CRC cells, while the overexpression of METTL3 increased the expression of miR-196b but reduced the expression of pri-miR-196b in CRC cells. The gene discussed is METTL3; the disease is colorectal carcinoma.