METTL3 and colorectal carcinoma: qRT-PCR showed that the knockdown of METTL3 significantly decreased the expression of miR-196b (Fig. 5c) but increased the expression of pri-miR-196b in CRC cells (Fig. 5d), while the overexpression of METTL3 increased the expression of miR-196b (Fig. 5e) but reduced the expression of pri-miR-196b in CRC cells (Fig. 5f).