In CRC, METTL3 has been reported to regulate metastasis by m6A-dependent posttranscriptional modification of SOX2, HK2, GLUT1, YPEL5 and CRB3 (Li et al. 2019; Zhou et al. 2021a; Shen et al. 2020; Pan et al. 2022). This evidence concerns the gene YPEL5 and colorectal carcinoma.