In CRC, METTL3 has been reported to regulate metastasis by enhancing the mRNA stability of SOX2, HK2, GLUT1 and YPEL5 through an m6A-IGF2BP2/3-dependent mechanism (Li et al. 2019; Zhou et al. 2021a; Shen et al. 2020). Here, YPEL5 is linked to colorectal carcinoma.