EPN2 and glioblastoma: “Differentiating NPCs” from mt-samples were characterized by neuronal markers (SEMA5A, NCAM1, GRIA4, PTPRD, SNTG1, and LRRC4C), and a number of stem markers, e.g. EPN2 activating Notch signaling33, ATP1B2 distinguishing glioblastoma stem-like cells34, PREX2 inhibiting tumor suppressor PTEN35 (Fig. 4B, E).