The lower levels of LPC 16:0 and 18:0 observed in UGT2B28 KO is consistent with previous observations linking lower levels of LPC (16:0) to biochemical recurrence of PCa after prostatectomy and lower plasma levels of LPC (18:0) to an increased risk of PCa [56, 57]. Here, UGT2B28 is linked to posterior cortical atrophy.