A key observation is the different metabolomic perturbations in the circulation of UGT2B17 and UGT2B28 KO PCa cases, despite a shared 84.3% nucleotide sequence identity between the two genes, a similar tissue distribution (present in hepatic and prostate tissues) and overlapping steroidogenic substrates (Fig. 1 and Supplementary Fig. S1) [25, 44]. Here, UGT2B28 is linked to posterior cortical atrophy.