To increase the metabolome coverage, we used three platforms for untargeted and targeted metabolomics for characterisation of preoperative plasma specimens from 30 UGT2B17 KO, 24 UGT2B28 KO and 30 gene-proficient treatment-naive PCa cases undergoing prostatectomy (Fig. 2a). The gene discussed is UGT2B28; the disease is posterior cortical atrophy.