Functional glucuronidation assays support that the pregnanediol derivatives 5α-pregnan-3α,20α-diol and 5α-pregnan-3β,20α-diol are conjugated by UGT2B28 in LNCaP prostate cancer cells (Fig. 3d and Supplementary Fig. S1A). This evidence concerns the gene UGT2B28 and prostate carcinoma.