Compared with OPN, multivariable analysis revealed a trend towards better fulfilment of Trifecta outcomes with RPN (OR [95% CI] = 0.73 [0.51–1.05], p = 0.0879), and stratified analyses showed that Trifecta outcomes were more likely to be fulfilled with RPN for tumours > 7 cm (Supplementary Table 1). This evidence concerns the gene SPP1 and neoplasm.