CDKN1A and leukemia: Altogether, these results indicate that p21TD-Mo-based cellular therapy drives the engraftment of p21-transduced phagocytes, which, in addition to directing the elimination of leukemia cells, triggers the secretion of the proinflammatory cytokine IFNγ and supports the proinflammatory reprogramming of TAMs, which in turn participate in the regression of leukemia.