The decreased survival of mice observed after depletion of Co.TD-Mo-derived macrophages with clodronate-containing liposomes (Fig. 3l) and adoptive transfer of SIRPαTD-Mos (Fig. 3m) confirmed our in vitro results (Figs. 1 and 2) and demonstrated that the lentiviral transduction of p21 potentiated the intrinsic capacity of anti-inflammatory macrophages to engulf leukemia cells in vivo. The gene discussed is MOS; the disease is leukemia.