Altogether, these results highlighted that adoptive transfer of p21TD-Mos promotes the phagocytosis of CD47-expressing leukemia cells and significantly inhibits leukemia progression through the abrogation of the antiphagocytic CD47-SIRPα axis mediated by repressing SIRPα expression in TAMs differentiated from p21TD-Mos. The gene discussed is CD47; the disease is leukemia.