In addition to its direct effect on malignant cells (Supplementary Fig. 19 and refs. 41–44), IFNγ released by phagocytic macrophages can induce the proinflammatory reprogramming of neighboring nonphagocytic anti-inflammatory macrophages, thus supporting the possibility that inducing the TME accumulation of p21TD-Mo-derived macrophages with enhanced abilities to engulf leukemia cells and trigger the proinflammatory reprogramming of TAMs in situ could be an attractive alternative approach to overcome tumor immune evasion strategies12. This evidence concerns the gene IFNG and neoplasm.