IFNG and leukemia: In addition to its direct effect on malignant cells (Supplementary Fig. 19 and refs. 41–44), IFNγ released by phagocytic macrophages can induce the proinflammatory reprogramming of neighboring nonphagocytic anti-inflammatory macrophages, thus supporting the possibility that inducing the TME accumulation of p21TD-Mo-derived macrophages with enhanced abilities to engulf leukemia cells and trigger the proinflammatory reprogramming of TAMs in situ could be an attractive alternative approach to overcome tumor immune evasion strategies12.