Along with tangible therapeutic implications for future interventions, high expression of GZMK by infiltrating CD8+ TEM in response to CD15high neutrophils links them to tumor progression rather than anti-tumor function, suggesting that integrating functional information resulting from the crosstalk of CD8+ T cells with different components of the immune contexture and the stroma might implement the prognostic value of current biomarkers, which are mostly based on limited phenotypic or transcriptional CD8+ T cell characteristics. Here, GZMK is linked to neoplasm.