Finally, querying of publicly available CRC datasets on The Cancer Genome Atlas (TCGA) using CD8_Tem transcriptional signature (see Methods for details) showed a better prognosis in patients with lower infiltration of CD8_Tem expressing GZMK (Fig. 4G) and this was specific of the CD8_Tem, since none of the other lymphocyte signatures tested resulted into an equivalent stratification (Supplementary Figs 7B–D and Supplementary 8). This evidence concerns the gene CD8A and colorectal carcinoma.