CD8A and neoplasm: Indeed, in vivo neutrophils depletion (as assessed in bone marrow, blood, spleen, and tumors, Supplementary Fig. 9K) significantly reduced intratumoral frequencies of GZMKhigh CD8 T cells (Fig. 5H) paralleled by a reduction in the tumor size (Fig. 5I), demonstrating that the GZMKhigh CD8+ TEM-neutrophils crosstalk is conserved across species and contributes to tumor progression.