CEACAM8 and colorectal carcinoma: First, we showed by quantitative confocal microscopy on human CRC tumors that the contact (distance r ≤ 10 μm) with intratumoral neutrophils (CD66b+) was associated with levels of GZMK in CD8+ T cells higher than any other cell types (not-CD8+, Fig. 5J), confirming that the interaction is specific and possibly contact-mediated.