CD8A and colorectal carcinoma: While combining overall neutrophils with the cytolytic CD8+ T cell transcriptional signatures did not independently predict the clinical outcome (Supplementary Fig. 9A, p = 0.44), Pearson correlation analysis revealed that intratumoral CD15high neutrophils were positively correlated with GZMKhigh CD8+ TEM (Fig. 5A), which we have shown to effectively stratify CRC and LUAD patients.