CCN2 and cancer: Consistently, we found that MGH-CP1 and MGH-CP12 could potently inhibit TEAD–YAP transcriptional activities in TEAD-binding element driven luciferase reporter assays with IC50s of 1.68 μM and 0.91 μM, respectively (Fig. 1f and Supplementary Fig. 1g), and suppress the expression of the TEAD–YAP target genes similarly (CTGF, Cyr61 and ANKRD1) in cancer cell lines in qPCR assays (Fig. 1g).