In addition, MGH-CP1 and MGH-CP12 significantly inhibit tumor sphere formation in YAP-dependent liver cancer cell line (Huh7 cells) in a dose-dependent manner with IC50 values of 0.72 μM and 0.26 μM, respectively (Fig. 1h and Supplementary Fig. 1f), suggesting that the tumor sphere inhibition is correlated with its TEAD1 or TEAD2 inhibitory activities. This evidence concerns the gene TEAD2 and neoplasm.