With a subcutaneous model, we demonstrate that inhibition of CD39 (CD39i) by sodium polyoxotungstate (POM-1, a novel ENTPDase inhibitor)16 can inhibit BC growth and improve prognosis in vivo, which is associated with increased infiltration levels of CD8 + T cells and conventional type 1 dendritic cells (cDC1) in cancer tissues. This evidence concerns the gene ENTPD1 and breast cancer.