After quality control and batch effect removal, all the single cells from 8 BC samples and 3 paratumor samples14 were clustered into 10 major clusters based on known cellular markers (Fig. 1A, Supplementary Fig. 1C and Supplementary Fig. 2A), including epithelial cells, endothelial cells, smooth muscle cells and pericytes (SMC and peri), fibroblasts, myeloid cells, B cells, T and NK cells, mast cells, LYVE1 + cells, and plasma cells. Here, LYVE1 is linked to breast cancer.