Hepatic stellate cells are important hepatic cells that can secrete various inflammatory molecules and extracellular matrix components to aid the progression of hepatic inflammation and fibrosis.340,341 The effect of YAP/TAZ on the activation of hepatic stellate cells has been verified in multiple studies, supporting the importance of the Hippo pathway in the progression of hepatic inflammation and hepatic fibrosis.333,337,342. This evidence concerns the gene YAP1 and Hepatic fibrosis.