YAP1 and metabolic dysfunction-associated steatohepatitis: Hepatic fibrosis results from chronic liver damage, which can be caused by NASH, alcohol abuse or hepatitis virus infection.335 Carbon tetrachloride (CCl4) is a hepatotoxin that is widely used to establish hepatic fibrosis animal models.336 In hepatic fibrosis caused by CCl4 injection, YAP was increased in the nucleus and cytoplasm in hepatocytes and biliary cells from fibrotic livers.