TJP2 and neoplasm: This inhibitory role is associated with the tumour-suppressive effects of α-Catenin.73 In addition, Zonula occludens (ZO) proteins (ZO-1, ZO-2, ZO-3) are scaffolding proteins that provide a structural basis for tight junctions.74 It has been shown that ZO-2 silencing leads to the activation of YAP and causes renal hypertrophy.75