Cell death could be rescued by downregulating the Hippo pathway.326 In SOD1(G93A) mice, which are a commonly used mouse ALS model, genetic deletion of MST1 could improve spinal cord motor neuron viability and decrease mortality.327 Finally, in HD mice, deficiency in TEAD/YAP-dependent transcription could lead to necrotic cell death.328 In addition, LATS was activated in the brains of patients with HD.329. Here, MST1 is linked to Huntington disease.