In addition, the progression of coronary heart diseases and myocardial infarction may be related to changes in the Hippo pathway.296 YAP/TAZ activity is involved in atherogenesis, which is a characteristic of coronary heart disease.303 Interestingly, specific deletion of YAP in fibroblasts can effectively reduce the fibrotic response and improve cardiac function after myocardial infarction.304. This evidence concerns the gene YAP1 and myocardial infarction.