WWTR1 and inflammatory response: Hepatic stellate cells are important hepatic cells that can secrete various inflammatory molecules and extracellular matrix components to aid the progression of hepatic inflammation and fibrosis.340,341 The effect of YAP/TAZ on the activation of hepatic stellate cells has been verified in multiple studies, supporting the importance of the Hippo pathway in the progression of hepatic inflammation and hepatic fibrosis.333,337,342