In the IR injury model, YAP levels were increased along with the progression of renal fibrosis.319 In other renal injury models with renal fibrosis, such as the obstructive, aristolochic acid and diabetic nephropathy models, the expression of TAZ in the tubulointerstitium was elevated.320 In addition, MST1/2 deletion in renal tubule cells caused progressive renal interstitial fibrosis.319–321. This evidence concerns the gene MST1 and renal fibrosis.