Similar tumour suppressive activity of YAP/TAZ was observed in ER+ breast cancer,236 haematological cancers237 and several solid cancers of neural/neuroendocrine origin.238 In addition, deletion of the tumour suppressor’ LATS1/2 in cancer cells inhibits tumour growth in B16, SCC7 and 4T1 immunocompetent syngeneic mouse models in vivo due to enhanced immunogenicity of the cancer cells.41 These findings suggest that the Hippo pathway may play a tissue type-specific role in tumorigenesis. This evidence concerns the gene WWTR1 and breast cancer.