YAP1 and cancer: In addition, in human and mouse skin, YAP-TEAD activation promotes the proliferation of keratinocytes to maintain skin homoeostasis154,155 or mediate IL-17A-driven psoriasis.126 Moreover, the Hippo pathway regulates contact-dependent cell growth and proliferation in cancer cells,156,157 nervous Schwann cells,158 epidermal stem cells159 and hepatic160 or lung epithelial cells.161,162