WWTR1 and coronary artery disorder: In addition, the progression of coronary heart diseases and myocardial infarction may be related to changes in the Hippo pathway.296 YAP/TAZ activity is involved in atherogenesis, which is a characteristic of coronary heart disease.303 Interestingly, specific deletion of YAP in fibroblasts can effectively reduce the fibrotic response and improve cardiac function after myocardial infarction.304