In vitro, the A549 and HCC44 cells that express YAP1 5SA were shown to have selumetinib resistance.281 The combination of YAP suppression and MEK inhibition can induce apoptosis in NSCLC, melanoma, colon cancer and thyroid cancer harbouring BRAF V600E, while the MEK inhibitor alone can not induce this effect.282 Clinically, the increased YAP levels may decrease the efficacy of MEK inhibitors.282 Ultimately, in terms of EGFR tyrosine kinase inhibitor resistance, TAZ expression is one of the intrinsic mechanisms. The gene discussed is YAP1; the disease is colonic neoplasm.