MST1 and autoimmune disease: In addition, among the immune cells that can be regulated by the Hippo pathway, Treg cells and Th17 cells are worthy of attention because of their close connection to autoimmune diseases.352,353 It was reported that Mst1-Mst2 was essential for maintaining the Treg pool, while TAZ contributed to the production of Th17 cells and the function of Tregs.