Focusing on genes differentially expressed in the T cell subsets of ALS patients and controls, we found a set of genes that control for cellular cytotoxicity, including GNLY, GZMA, GZMB, GZMH, GZMK, PRF1, CTSW, KLRB, KLRD1, and NKG7 (Fig. 3C). This evidence concerns the gene GZMA and amyotrophic lateral sclerosis.