A potent driver of mitochondrial biogenesis is the oncogene c-myc and consequently increased c-Myc expression represents a hallmark of Burkitt lymphoma and B cell and T cell acute lymphoblastic leukemias (ALL) [31] which might explain the high sensitivity of the Burkitt lymphoma cell line Ramos to VDT-induced cytotoxicity. This evidence concerns the gene MYC and acute lymphoblastic leukemia.