Interestingly, Rai et al. demonstrated that fibroblasts activated by late-stage cancer-exosomes (SW620-Exos) display elevated expression of proteins (PDLIM1, MYO1B, MMP11, EMMPRIN, ADAM10) that support invasive outgrowth and metastasis, which is consistent with our conclusions on the importance of Myo1b in facilitating CRC progression [32]. This evidence concerns the gene PDLIM1 and cancer.