As shown in Fig. 2B, Myo1b knockdown obviously suppressed the mRNA expression of Ang-II, BFGF-B, DLL4, IL-8, PLGF, PDGF and VEGF-A in HCT-116 cell while Myo1b over-expression showed opposite phenomenon in HT29 cells, indicating that the potential of Myo1b in CRC angiogenesis. The gene discussed is CXCL8; the disease is colorectal carcinoma.