We proposed a pro-oncogenic model in which on the one hand, the HNRNPU-DDX complex activates the Wnt/β-Catenin pathway by modulating the intron retention (RI) rate of minichromosome maintenance protein 10 (MCM10, a protein required for DNA replication) [29, 30]; on the other hand, the HNRNPU-DDX complex is located near the promoter of LIM domain only protein 4 (LMO4, an oncogene that was reported to promote the invasion and proliferation of cancer cells) and activates transcription and the PI3K/Akt pathway. The gene discussed is AKT1; the disease is cancer.