Furthermore, HCC progression is regulated by the cell cycle (ko04110), and multiple upregulated DEGs were found to be significantly enriched in this pathway, including multiple cell cycle-related regulatory genes (CCNB3, PCNA, CDK1, CDK4, CCNB1, CCNB2, and CHEK1). The gene discussed is CCNB3; the disease is hepatocellular carcinoma.