Among them, CDK1, CDK4, G6PD, AURKA, MMP9, IGFBP3, and CHEK1 were considered risk factors in LIHC, and 6 of the 7 genes (CDK1, CHEK1, MMP9, G6PD, CDK4, and AURKA) were abnormally highly expressed in HCC patients. The gene discussed is CDK4; the disease is hepatocellular carcinoma.