AKR1D1 and hepatocellular carcinoma: The study by Cao et al. [36] showed that knockdown of G6PD in HCC reduced tumor volume and tumor weight in vivo. Data from Nikolaou et al. [37] suggest that AKR1D1 may play an important role in regulating endogenous glucocorticoid action, which may be particularly relevant to physiological and pathophysiological processes affecting the liver.