Among them, the metabolic pathway (ko01100) in HCC involves abnormal changes in multiple metabolic genes, including high DNMT3A, G6PD, PGP, and EZH2 expression and low AKR1D1, SLC27A5, XDH, LDHD, and ADH3 expression. The gene discussed is XDH; the disease is hepatocellular carcinoma.