The study by Cao et al. [36] showed that knockdown of G6PD in HCC reduced tumor volume and tumor weight in vivo. Data from Nikolaou et al. [37] suggest that AKR1D1 may play an important role in regulating endogenous glucocorticoid action, which may be particularly relevant to physiological and pathophysiological processes affecting the liver. Here, AKR1D1 is linked to neoplasm.