Furthermore, aberrant expression of METTL3 was involved in the dysfunction of cellular signaling pathways, such as MAPK [74], JAK/STAT [78], PI3K/AKT [79, 80] and Wnt/β-catenin [81] cascades, which are involved in tumor progression, metastasis, migration and stemness. This evidence concerns the gene AKT1 and neoplasm.