Detailed analyses of tumoral molecular markers have previously also been associated with brain atrophy (e.g. IDH status [43], 1p/19q co-deletion and TERT promoter mutation [44, 45]) and cognitive performance (e.g. IDH-1 expression, CD3, ATRX, BDNF, EAAT1, GAT-3, SRF, NLGN3, CK2Beta and P-STAT5b, NLGN3 and CK2Beta [45]). This evidence concerns the gene NLGN3 and Brain atrophy.