NOS2 and ischemic stroke: Yet, bone marrow–derived MDCs also express a core inflammatory gene signature following ischaemic stroke, through the induction of type I interferon (IFN), inducible nitric oxide synthase (iNOS), IL-1β, and IL-6 genes and retain capacity to produce IL-1β and tumour necrosis factor (TNF)α ex vivo [37, 56, 59, 88].