Matrix metalloproteinases (MMP‐1, −2, −3, −9 and − 13) cleave SPARC in vitro in its N‐terminal acid domain and in its extracellular Ca2+ binding domain, releasing fragments that have higher affinity for collagens and that modulate cell‐cell and cell‐matrix extracellular interactions in the tumor microenvironment.56 Here, SPARC is linked to neoplasm.