WDR35 and ciliopathy: These and other ciliopathy-associated missense variants in the WD40 domains of IFT122, including S373F and V553G, also disrupt the association of the IFT-A core with the IFT-A peripheral proteins, IFT121 and IFT43 (Takahara et al., 2018), and the positions of all of these alleles near those interfaces in our model are consistent with this result (Figure 8C).