Likewise, loss of IFT122 results in ciliogenesis defects (Takahara et al., 2018), but cilia can be rescued by the ciliopathy-associated variants such as the W7C and G513V alleles (Takahara et al., 2018), which do not map to the TPR domains but instead to the WD40 repeats (Figure 8C). Here, IFT122 is linked to ciliopathy.