These and other ciliopathy-associated missense variants in the WD40 domains of IFT122, including S373F and V553G, also disrupt the association of the IFT-A core with the IFT-A peripheral proteins, IFT121 and IFT43 (Takahara et al., 2018), and the positions of all of these alleles near those interfaces in our model are consistent with this result (Figure 8C). Here, IFT43 is linked to ciliopathy.