TPR and ciliopathy: Likewise, loss of IFT122 results in ciliogenesis defects (Takahara et al., 2018), but cilia can be rescued by the ciliopathy-associated variants such as the W7C and G513V alleles (Takahara et al., 2018), which do not map to the TPR domains but instead to the WD40 repeats (Figure 8C).