The ESRP1/2 genes (Warzecha et al., 2009), the ‘splicing masterminds’ of EMT (Tavanez and Valcárcel, 2010; Warzecha et al., 2010), were found among the top downregulated RBP-coding genes in EpCAMlo colon cancer cells, as part of a self-enforcing feedback loop with the EMT-TF ZEB1 (Preca et al., 2015). The gene discussed is ESRP1; the disease is colonic neoplasm.