In order to identify differentially spliced target genes in RBP-specific fashion, we took advantage of RNAseq data sets from previous ESRP1-, ESRP2-, RBM47-, and QKI-KD studies in different cancer cell lines and compared them with our own AS data relative to the EpCAMhi/lo colon cancer subpopulations (Sacchetti et al., 2021; Figure 2A and Figure 2—figure supplement 1). This evidence concerns the gene ESRP1 and malignant colon neoplasm.