On the other hand, the increased expression of other RBP-coding genes such as RBM24 and MBNL2 (muscleblind-like 2) in CMS4 tumors and in EpCAMlo cells is in sharp contradiction with their alleged tumor suppressing roles in colon and other cancers (Xia et al., 2021; Lin et al., 2021). This evidence concerns the gene MBNL2 and cancer.