ZEB1 and malignant colon neoplasm: Accordingly, among the top differentially expressed genes (DEGs) between EpCAMlo and EpCAMhi in SW480 and HCT116 colon cancer cells, ESRP1 was found to be downregulated both at the RNA and at the protein level in the quasi-mesenchymal subpopulation where ZEB1 expression is upregulated (Figure 1A–C).