LRG1 and obesity due to melanocortin 4 receptor deficiency: Multiple biomarker studies in humans have shown that increased LRG1 is associated with not only obesity (Pek et al., 2018) but also conditions involving cell death and inflammation, such as appendicitis (Kentsis et al., 2010), solid tumors (Belczacka et al., 2019) and autoimmune diseases (Naka and Fujimoto, 2018).