As shown in Figure 4, the anti-HIV duoCAR T cells potently suppressed HIV infection in HIV-infected monocytes by 85.3% (Figure 4A), PBMCs by 91.5% (Figure 4B), and CD4+ T cells by 92.6% (Figure 4C), as compared with treatment with UTD control T cells. This evidence concerns the gene CD4 and HIV infectious disease.