CD8+ T cell–depleted PBMCs from these donors were superinfected with a HIV-LucR IMC expressing the BaL Env and cocultured with autologous MND-ΔW duoCAR T cells either immediately following the initiation of HIV-LucR infection (Figure 5A, acute infection) or 3 days later, after HIV-LucR infection had been established (Figure 5B, established infection). Here, CD8A is linked to infection.