Cd72-Sema4d–mediated interactions were also predicted to reinforce physical associations between lupus-associated TrMac subsets (MNP1.4 and MNP1.5) and MoMac subsets in the context of nephritis (Figure 5A), which was further supported by the expression of Sema4d in large CD11bhi MNP2 infiltrates (Figure 5D) as well as the coexpression of these molecules in MRL-Lpr kidneys (Figure 5C). Here, SEMA4D is linked to systemic lupus erythematosus.