Interestingly, as observed in murine MRL-Lpr MNP1 clusters, TNFSF13B (encoding BAFF) expression was increased in TrMacs in human lupus nephritis compared with control kidneys (Figure 8D), and macrophage BAFF expression was validated in biopsies obtained from patients with lupus nephritis (Figure 8E). This evidence concerns the gene TNFSF13B and lupus nephritis.