Macrophage IgG IC stimulation results in the generation of proinflammatory cytokines and mediators (5, 6); therefore unsurprisingly, FCGR polymorphisms that augment FcγR-mediated macrophage activation are associated with susceptibility to SLE and lupus nephritis (5, 7). This evidence concerns the gene FCGR2A and systemic lupus erythematosus.