This phosphorylation is mediated by the phosphoinositide-3-kinase γ (PI3Kγ) and Casein kinase 2 (CK2) and it has been correlated to aberrant cytosolic retention of SET in Alzheimer’s disease [30,31,97,98], in myeloproliferative neoplasms (MPNs) and AML [56,99]. This evidence concerns the gene SET and early-onset autosomal dominant Alzheimer disease.