Indeed, SET knockdown suppressed cell anchorage and colony formation ability in CIP-m but not CIP-p and, at the metastatic stage, the antitumor effect of SET knockdown was found associated with PP2A re-activation and decreased levels of some of the main targets of PP2A, including phospho -GSK3-β and β-catenin. This evidence concerns the gene GSK3B and hereditary sensory and autonomic neuropathy.