The interaction between SET and the GR responsive elements (GREs) on target gene promoters has profound implications on the resistance of SET-NUP214 T-cell Acute Lymphoblastic Leukemia (T-ALL) to corticosteroids, possibly due to inappropriate transcriptional regulation of GR target genes, as described in the following paragraphs [41]. The gene discussed is SET; the disease is T-cell acute lymphoblastic leukemia.