Moreover, overexpression of SET fails to induce up-regulation of ATM, BRCA1 and CHK2 and recruitment of BRCA2 to DNA damage foci in head and neck squamous cell carcinoma (HNSCC) lines upon cisplatin treatment, suggesting another important inhibitory role of SET on DNA damage repair [50]. Here, CHEK2 is linked to head and neck squamous cell carcinoma.