This phosphorylation is mediated by the phosphoinositide-3-kinase γ (PI3Kγ) and Casein kinase 2 (CK2) and it has been correlated to aberrant cytosolic retention of SET in Alzheimer’s disease [30,31,97,98], in myeloproliferative neoplasms (MPNs) and AML [56,99]. The gene discussed is SET; the disease is acute myeloid leukemia.