Wei et al. were the first to identify a signaling pathway mediated by SET-phospho-MDM2-p53 in p53-wild-type Sonic Hedgehog (SHH) medulloblastoma, a subgroup of medulloblastoma representing approximately 30% of all medulloblastoma cases and characterized by activation of SHH pathway. This evidence concerns the gene MDM2 and medulloblastoma.