GINS1 and neoplasm: Together, we annotated six subtypes by specific immune features: (i) GINS1/3, thereafter designated the ‘immune-desert’ phenotype, was endowed with scarce immune fractions; (ii) GINS2, thereafter designated the ‘immune-suppressed’ phenotype, was enriched for abundant inhibitory cells; (iii) GINS5, thereafter designated the ‘immune-activated’ phenotype, was dramatically linked to superior tumor immunogenicity and extensive immune activation; and (iv) GINS4/6, thereafter designated the ‘mixed’ phenotype, was characterized by moderate levels of immunity cycle score (Figure 6F).