Apart from the immune activation represented by GINS5, GINS1/2/3 displayed sparse infiltration of cells that promote immune activity (Figure 6D and Figure 6—figure supplement 1A-C), but unlike GINS2, GINS1/3 were also characterized by rare immunosuppressive cells (Figure 6E and Figure 6—figure supplement 1D), consistent with their high tumor purity. Here, GINS2 is linked to neoplasm.