For instance, Astragalus membranaceus could promote vascular normalization in tumor-derived endothelial cells of HCC by reduced expression of HIF1a [10], and the standardized extract of Astragalus membranaceus and Paeonia lactiflora caused significant inhibition of cell proliferation, migration, and invasion effect in HCC cells [11]. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.