STAT3 and hepatocellular carcinoma: The result of UALCAN showed that the mRNA expression levels of TP53, AKT1, MAPK1, MAPK3, SRC, PIK3CA, HRAS, MAPK8, KRAS, RHOA, and RAC1 in HCC samples were significantly higher than that in normal liver tissues, the mRNA expression of JUN in HCC was lower than that in normal liver tissue, and there was no significant difference in the mRNA expression of STAT3, EGFR, and PIK3R1 (Figure 6).