The neurofilament light (gene nameNEFLSynonyms: NF68, NFL), has been proposed to be a tumor suppressor gene in different cancers.NEFLis located at chromosome 8p21 loci where mutations heterozygous and homozygous and loss of heterozygosity are observed in several cancers (Macoska et al., 1995; Vocke et al., 1996; Häggman et al., 1997; Takimoto et al., 2001; Coon et al., 2004; Burke et al., 2006; Schmidt et al., 2007). The gene discussed is NEFL; the disease is cancer.