MAPK3 and neoplasm: Furthermore, we detected markers associated with tumor metastasis via western blot and found that solamargine downregulated protein levels of MMP2 and MMP9 in cervical cancer cells (Figures 5(e) and 5(f), p < 0.001), which were partially abrogated with the addition of CXCL3 overexpression (Figures 5(e) and 5(f), p < 0.001), whereas this effect of solamargine in CXCL3-overexpressing tumor cells was restored after Erk1/2 blocking (Figures 5(e) and 5(f), p < 0.01).