In order to investigate whether solamargine regulates the Erk signaling pathway by modulating target mRNAs, we screened out genes that regulate this pathway in cervical cancer including PBK, RACK1, CXCL3, TRIP4, and SEMA3C, which have been reported in the literature in recent years [25–29]. This evidence concerns the gene SEMA3C and cervical carcinoma.