Pregnancy-associated plasma protein-A2 (PAPPA2) is a metalloproteinase that is responsible for proteolytic cleavage of a subset of insulin-like growth factor (IGF) binding proteins with subsequent release of IGF1, and has been implicated in promoting tumor cell proliferation, invasion, migration, and metastasis in other malignancies.27 The gene discussed is PAPPA2; the disease is neoplasm.