IRF3 and Alzheimer disease: In line with the presence of IFN-related pathways (Figures 3E–3H), there was a clear enrichment of motifs for IFN-induced TFs, including IFN-stimulated response element (ISRE), IRF1, IRF3, IRF8, and type I IFN-stimulated response element (T1ISRE), when comparing MS to T1D or T2D and AD to MS or T1D (Figures S5E–S5H).