TF and type 1 diabetes mellitus: Analysis of TF binding sites in promoter regions (transcription start site ± 2 kb) of differentially expressed genes for each disease identified a clear enrichment of IFN-induced TFs in the upregulated genes of T1D, including IFN regulatory factor 1 (IRF1), IRF2, and IRF8 (Figure S2A), which is in line with the marked induction of IFN-related pathways in T1D (Figure 1B).