Moreover, we also found that the AUC training the methylation levels of 985 signature methylation features related to TIIC-like CD8+T cells, DCs, and PBMC-like DCs, which were the best cell combination for predicting cancer recurrence, was still significantly lower than the AUC using the cell deconvolution result (p value = 2.1 × 10−6). The gene discussed is CD8A; the disease is cancer.