DPP‐4, the enzyme that converts PYY1‐36 to PYY3‐36, is thought to be a mediator of the link between obesity and diabetes by inactivating incretins such as GLP‐1, and regulating inflammation and insulin resistance in the liver and adipose tissue.23 The gene discussed is DPP4; the disease is obesity due to melanocortin 4 receptor deficiency.