Moreover, cross-sectional studies reported that tau-PET patterns closely mirror clinical AD heterogeneity, including occipital tau-PET in posterior cortical atrophy (i.e., visual-variant AD), left-hemispheric tau-PET in language-variant AD, and mesial-temporal-lobe tau in amnestic AD [14, 15]. The gene discussed is MAPT; the disease is Alzheimer disease.