In ADNI Aβ+, bootstrapped linear regression revealed cognitive-domain-specific tau-PET as a better predictor of cognitive decline than global/temporal tau-PET for MEM (cognitive-domain-specific/global/temporal tau-PET: partial R2 = 0.175/0.108/0.152; Fig. 2A), LAN (cognitive-domain-specific/global/temporal tau-PET: partial R2 = 0.201/0.164/0.136; Fig. 2B), EF (cognitive-domain-specific/global/temporal tau-PET: partial R2 = 0.132/0.088/0.029; Fig. 2C), and VS (cognitive-domain-specific/global/temporal tau-PET: partial R2 = 0.192/0.097/0.070; Fig. 2D). Here, MAPT is linked to Mental deterioration.