In stratified analysis by PRS-AD, a nominal statistically significant association was found between SNPs predicting longer TL and lower levels of CSF p-tau only in individuals classified as high genetic predisposition to AD [βIVW = −9.186, SE = 4.534, p-value = 0.043] (Fig. 4; Table 2). The gene discussed is MAPT; the disease is Alzheimer disease.