RB1 and hepatocellular carcinoma: The most commonly altered genetic variants in HCC include mutations of the TERT promoter, CTNNB1, TP53, RB1, CCNA2, CCNE1, PTEN, ARID1A, ARID2, RPS6KA3 or NFE2L2, CCND1, FGF19, VEGFA, MYC and MET [21, 22], leading to changes in TERT, Wnt/β-catenin, p53/p21 and RB1, AKT-mTOR, RAS-MAPK, VEGF/VEGFR, MET, IGF, ARID1A/ARID1B/ARID2 pathways.